Mohamed Chaker achieved a major breakthrough with his 2025 duet "Kifek 3A Fra2e" alongside his father, Fadel Chaker. The song was more than a family collaboration; it became a milestone in his career, topping the Billboard Arabia Hot 100 chart. It also garnered over 100 million views on YouTube within just three months of its release, solidifying his position as a powerful emerging artist in the Arab music scene. In 2018, Chaker dedicated a special song to his father titled "Aarfinak" for his birthday, with lyrics and music by Salah Al-Kurdi. The song resonated emotionally with the public, as it expressed Mohamed's unwavering support for his father during a challenging period, highlighting their close bond. Chaker released his first-ever duet in 2020, collaborating with artist Rima Youssef on the track "Habibi Elli." The song, written and composed by Youssef and arranged by Abbas Sabbah, explored the theme of long-distance relationships and showcased his ability to deliver successful collaborative musical works.